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AortaCore-Aortic Imaging Lab

Dr. Jon Matsumura's Aortic Imaging Lab performs an independent analysis of radiographic imaging involving different pathophysiology of the aorta including aneurysms, dissections, and traumatic aortic injury. Currently AortaCore provides pre and post-operative image interpretation and analysis for multi-center, prospective clinical research trials determing the safety and efficacy of medical treatments for aortic aneurysm and endovascular repair of aortic dissection, descending thoracic aortic aneurysms, and traumatic transections. AortaCore uses advance technology to provide objective processing of imaging data received as part of these clinical research trials. AortaCore provides protocol-defined image processing. Specifically we assess images for change in aortic anatomy as a result of treatment, device performance, and measuring parameters such as diameter and volume. Dr. Matsumura is also currently involved in multiple ongoing clinical trials involving treatment of patients with vascular diseases. His clinical area of expertise involves advanced percutaneous endovascular interventions for carotid stenosis, aortic aneurysm, aortic dissection, and peripheral artery disease.
Jon S Matsumura, MD
Wendy Meadows, RN
Jennifer Grudzinski, RT
Hillary Alberta
Taylor Smits
Brad Wendorff

Cardiothoracic Core Lab

The mission of the Cardiothoracic Core Laboratory is to provide innovative, state-of-the-art, affordable models of intravital microscopy to UW and non-UW researchers. While the central focus of the laboratory is cardiovascular research, the models employed are also useful to investigators in other fields. One of the most popular services provided by the lab is evaluation of the angiogenesis in an in vivo mouse model.
Entela Lushaj, MD, PhD
Lucian Lozonschi, MD
Takushi Kohmoto, MD, PhD

Dr. Bo Liu's Lab

The primary focus of Dr. Liu’s research is the biology of blood vessels. Specifically, Dr. Liu and her trainees study the cellular and molecular pathologies of restenosis and abdominal aortic aneurysm, two common vascular disorders that are in critical need of effective pharmacological treatments. Their experimental approach combines in vitro molecular and biochemical methodologies with transgenic, gene knockout, adenoviral and surgical technologies. Current research topics include cell apoptosis, programmed necrosis, vascular inflammation, progenitor cell recruitment, as well as matrix biology. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, whose lab environment fosters creative thinking, multidisciplinary approaches, independence, and collaboration.
Bo Liu, PhD
Danielle Stewart, PhD
Kartik Gupta, MS
Carmel Assa
Benjamin Mills
Ting Zhou, PhD

Dr. Burlingham's Lab

The research interests of Dr. Burlingham's lab include: 1) mechanisms of natural and induced forms tolerance to allografts, b) microchimerism and mixed chimerism approaches to tolerance, c) T cell biology, especially immunobiology of alloantigen- and tumor- specific T regulatory cells, and d) the role of collagen V-specific Th17 cells in fibro-obliterative diseases of heart & lung, and in lung transplant chronic rejection(OB).
William J Burlingham, PhD
Ewa Jankowska Gan
Lynn D Haynes
Ying Zhou
Matthew E Brown
William Bracamonte-Baran, MD
Vrushali V. Agashe, MS

Dr. Ciucci's Lab

Michelle R Ciucci, PhD
Laura Grant
Eunice Paul Rajamanickam
Breanna Hilby
Jessica Martalock
Katie Blue
Kaylee Cullen

Dr. Connor's Lab

Nadine P Connor, PhD
Michael Hammer, PhD
Heidi Kletzien
John Russell

Dr. Dailey's Lab

Seth H Dailey, MD
Ben Bauer
Kim Linson
Karl Ng
Shanlee Stevens

Dr. Gosain's Lab

Hirschsprung's Disease (HSCR) patients that develop Hirschsprung's-associated Enterocolitis (HAEC) have worse long-term bowel function than those that never develop HAEC, possibly secondary to inflammatory changes to the enteric nervous system (ENS). A functioning ENS, which controls motility, water and nutrient absorption, and local blood flow, is essential to life. Common gastrointestinal diseases in the pediatric population, such as anorectal malformations, intestinal atresias, and motility disorders are associated with disturbances in basic ENS functions, and are likely associated with subtle, underappreciated, anatomic changes in the ENS as well as mucosal immune system. Additionally, recent evidence indicates that there are perturbations in ENS form and function in the setting of inflammatory bowel disease-related colitis, as well as age- and severity of disease-related declines in ENS function in diabetes mellitus. Taken in this context, Hirschsprung’s disease can be considered a forme fruste of enteric nervous system dysfunction and is an ideal model system for studying gastrointestinal immune function in the presence and absence of the ENS. The long-term goal of our research is to gain an understanding of the interactions between the Enteric Nervous System and Gastrointestinal Immune System in both development and disease to permit the generation of novel neuro-immunomodulatory therapies that may potentially target a broad range of congenital and acquired pediatric gastrointestinal tract diseases (Hirschsprung’s disease, Necrotizing Enterocolitis, Intestinal Atresia, Motility Disorders, Inflammatory Bowel Disease, etc.).
Amanda Barlow, PhD

Dr. Greenberg's Lab


Dr. Guo's Lab

Dr. Lian-Wang Guo's laboratory is interested in identifying novel causative processes in the development of restenosis, a common recurrent vascular disease.
Lian-Wang Guo, PhD
Tim Mavlyutov, PhD
Huan Yang, PhD
Mengxue Zhang, MS
Lei Zhao, PhD
Yingmei Fu, PhD
Annie Yao

Dr. Jiang's Lab

Dr. Jiang's research focuses on objective pathological laryngeal function assessments, laryngeal physiology, biomechanics of vocal fold vibration, medical instrumentation, medical software development and application.
Jack J Jiang, MD, PhD

Dr. Kudsk's Lab

Dr. Kudsk's principal research interest is the effect route and type of nutrition and malnutrition on host defenses, mucosal immunity, and vascular inflammatory responses.
Kenneth Allan Kudsk, MD

Dr. Odorico's Lab

My laboratory team studies pancreatic lineage differentiation, including the differentiation of insulin-producing islet endocrine cells, from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). The work is designed to address two critical needs. First is the need to generate an unlimited supply of functional insulin-secreting beta cells to be used to replace damaged beta cells in patients with diabetes. Second is the need for a cell culture model to study, specifically, human pancreas and islet development, given known differences between humans and lower organisms and the inability to study human organ development in vivo. In our work, we have developed an in vitro model of human pancreas development using a well-characterized protocol to differentiate pluripotent stem cells toward the pancreatic lineage. Using this model we are investigating the role of transcription factors, as well as intercellular and intracellular signaling pathways at different stages of development. We have also developed cell sorting techniques to simultaneously isolate foregut progenitor cells and eliminate the teratoma promoting ESCs from mixed differentiated stem cell populations. More recently, we are investigating the role of extracellular matrix (ECM) in regulating differentiation of pancreatic progenitors with our collaborators. We are combining innovative technologies in stem cell biology (generation of iPSCs and novel pancreatic lineage differentiation protocols) and matrix biology (perfusion and spin decellularization of tissues to produce pancreas ECM) in order to establish and characterize an in vitro system which can be used to study human pancreatic stem cell-pancreatic ECM interactions. Other projects involve using tet-Ptf1a cells, a unique cell line having inducible over-expression of Ptf1a, to investigate the role of PTF1a in pancreatic progenitor cell formation and its interaction with other transcription factors in pancreas development. Lastly, we are actively testing the ability of human ESC/iPSC-derived pancreatic progenitors to mature and function to regulate blood glucose levels in diabetic mice.
Jon S Odorico, MD
Gopika Nair
Xiang (Grace) Li, MS
Sara D Sackett, PhD
Daniel M Tremmel

Dr. Thibeault's Lab

The Thibeault lab's translational research investigates molecular and genetic factors that are the basis of normal vocal fold tissue and its vibration. Dr Thibeault studies vocal fold injury and wound healing as a disordered model. Specifically, Dr Thibeault's lab has two main areas of study -- tissue engineering of the vocal fold lamina propria and laryngeal immunology. The lab has developed unique primary and immortalized human cell lines, in addition to vibrational bioreactors to aid in the research pursuit.
Susan Thibeault, PhD, CCC-SLP

Dr. Yamanouchi's Lab

The major focus of Dr. Yamanouchi’lab is to understand the pathogenesis of abdominal aortic aneurysm and restenosis after angioplasty including balloon angioplasty and stent placement. Especially throught the calcium regulation in the arteriosclerotic disease. Arterial calcification, commonly associated with aging and atherosclerosis, has recently attracted significant attention in the research community. Arterial calcification displays features of the highly organized processes seen in bone formation. Bone homeostasis is a carefully controlled system relying upon a delicate balance between mineral deposition and resorption as mediated by osteoblasts and osteoclasts, respectively. The presence of osteoclast-like cells (OLCs), which are derived from the monocyte/macrophage lineage and share osteoclast features such as the ability to dissolve extracellular matrix, has been noted in calcified arteries. Calcification is seldom considered a major feature of abdominal aortic aneurysm (AAA) and thus has remained a poorly explored avenue of study. This grant is aimed to explore the role of osteoclastogenesis, the development of OLCs, in AAA. They are also devoted to the development of novel materials for vascular bypass graft and gene delivery method to treat the patients who suffers peripheral arterial disease.
Dai Yamanouchi, MD, PhD
Natsumi Shiotani
Sandy Hughes

Islet Research Lab

Luis A Fernandez, MD
Juan Sebastian Danobeitia, MD, PhD
Peter Chlebeck
Laura Zitur, MS

The Patient Preferences Project: Better Communication for Surgical Decision Making

Dr. Schwarze is a board-certified vascular surgeon and medical ethicist. She is a nationally recognized expert in surgical decision making, informed consent, advance directives and end-of-life care. Her research focuses on improving communication between older patients and their surgeons, so that patients can avoid unwanted treatment and make decisions that align with their values, preferences and goals.
Margaret L Schwarze, MD, MPP
Michael Nabozny, MD
Lauren Taylor, MD
Jennifer Tucholka
Anne Buffington

UW Colon and Rectal Surgery Lab

The mission of the UW Colon and Rectal Surgery Laboratory is two fold. First we hope to contribute positively to the understanding of the etiology of colon and rectal cancer. We hope that these contributions will utlimately lead to not only a better understanding of behaviors that modify risk for cancer, but also to novel therapies that will ultimately improve outcomes. Second, we strive to provide an outstanding training environment in which we will train the next generation of both surgeons and scientists.

Wisconsin Vascular and Endovascular Research Network (WiVERN)

The Wisconsin Vascular and Endovascular Research Network (WiVERN) is a part of the Wisconsin Surgical Outcomes Research Program (WiSOR) and the University of Wisconsin Department of Surgery. Under the leadership of Sara Fernandes-Taylor, PhD, and K. Craig Kent, MD, the lab takes a data-driven, patient-centered approach to improving vascular surgical care and easing postoperative transitions from hospital to home.
Sara Fernandes-Taylor, PhD
K. Craig Kent, MD
Dai Yamanouchi, MD, PhD
Jon S Matsumura, MD
Caprice C. Greenberg, MD, MPH

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